evaluation of tricuspid regurgitant jet velocity in thalassemia patients with splenectomy
نویسندگان
چکیده
conclusions the etiology of pah in thalassemia is multifactorial such as inflammatory mediators. also, the absence of the spleen plays an important role in developing a high trv and pah. results average age of the patients was 21.15 ± 6.68 years. no significant difference was observed in the pap between the 2 groups of thalassemia major and intermedia and also the 2 sex groups. indeed, 6.6% of the patients had an increased pap. the significant finding of the study was that the patients who had had splenectomy were significantly at an increased risk of pah (p = 0.046). methods a total of 137 patients suffering from β-thalassemia were evaluated during the study. all subjects were referred for cardiac evaluation. clinical history, presence of cardiac symptoms, and previous splenectomy were noted. standard m-mode, 2d, and doppler echocardiographic examinations were performed for all subjects. patients with a tricuspid regurgitant jet velocity (trv) ≥ 2.5 m/s were considered at risk for pah. objectives this study aimed to assess the pap in patients with β-thalassemia (male or female and major or intermedia) who had undergone splenectomy. background β-thalassemia is an inherited disorder of β-globin biosynthesis. dysfunction in hemoglobin chain production, ineffective erythropoiesis, and hemolysis occur in β-thalassemia. pulmonary arterial hypertension (pah) is increasingly detected in patients with β-thalassemia, and splenectomy which decreases the need for blood transfusion increases the pulmonary artery pressure (pap).
منابع مشابه
Tricuspid regurgitant jet velocity and hospitalization in Tanzanian children with sickle cell anemia.
متن کامل
Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report.
An elevated tricuspid regurgitant jet velocity (TRV) is associated with hemolysis and early mortality in sickle cell disease, yet risk factors, clinical parameters, and mortality associated with this biomarker in thalassemia are poorly defined. This report summarizes the prevalence of an elevated TRV in 325 patients screened by Doppler echocardiography in the Thalassemia Clinical Research Netwo...
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BACKGROUND Elevation of echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. The definition, prevalence and clinical correlates of elevated jet velocity have not been established in pediatric patients. The present study tested the hypotheses that elevated jet velocity affects 10% o...
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عنوان ژورنال:
archives of cardiovascular imagingجلد ۴، شماره ۱، صفحات ۰-۰
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